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The Conference Board C-Suite Challenge™ 2021 examines the issues business leaders say are keeping them up at night. Globally CEOs expressed concerns about the ongoing COVID-19 pandemic and recession but are hopeful about the widespread availability of a vaccine as a game changer in 2021. US CEOs ranked concerns about higher corporate taxes and increased regulation higher than their global peers but ranked global political instability and disruptions to global trade lower than did CEOs worldwide. Unlike leaders outside the US, American CEOs are placing a high priority on employees returning to the physical workplace. The C-Suite Challenge surveyed more than 900 CEOs and 600 C-suite executives in late 2020.