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Meeting the regulation and risk challenge in 2017 means dealing with the effects of unprecedented disruption, from the fallout of the 2008 financial crisis to geopolitical uncertainty to the effects of technological change. Organizations are responding to these anxiety producers with a variety of strategies, say CEOs in our annual survey. They are updating contingency plans and crisis procedures that go beyond their own corporate walls to manage external risk factors and secure supply chains. They are exercising fiscal prudence, tackling cyber risk internally and externally, and in general looking to improve their agility in these uncertain times.