Leadership in the 21^st century will require very different abilities, not merely the same ones of today performed at a faster pace. Evolving technology, shifting values, and intensifying media scrutiny are just three of the challenges that will confront tomorrow's leaders. The CEOs of Merck and Sprint offer insights into meeting these challenges and developing models to ensure future success. Leaders at Harvard University, the Peace Corps, Booz•Allen & Hamilton, and Time offer additional advice. (12 pages)